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目的 探讨 10 %高渗氯化钠在治疗充血性心力衰竭 (CHF)伴有低钠血症时的安全性和有效性。方法 选择 110例CHF伴有低钠血症的患者 ,在常规综合治疗 (休息、吸氧、强心、利尿、扩血管 )及治疗原发病等综合治疗的基础上 ,对治疗组 6 0例和对照组 5 0例进行对比分析。治疗组在限水的同时给予 10 %氯化钠治疗。对照组限水但不补钠。观察治疗前后两组血钠浓度、血钠与心功能改善时间。结果 治疗组和对照组治疗前血钠浓度分别为 (12 7.13± 4 .99)mmol/L、(12 6 .0 2± 5 .98)mmol/L(P >0 .0 5 ) ;治疗后分别为(137.38± 4 .5 4 )mmol/L、(12 4 .36± 8.72 )mmol/L(P <0 .0 1)。治疗组和对照组治疗后血钠改善时间分别为 (3.72± 2 .0 5 )天与 (10 .72± 5 .2 8)天 (P <0 .0 1)。心功能改善时间分别为 (6 .4 0± 3.10 )天、(10 .5 8± 4 .2 1)天 (P <0 .0 1)。结论 10 %氯化钠在CHF低钠血症时的应用安全有效 ,可使低钠血症和心功能在短期内得到改善。
Objective To investigate the safety and efficacy of 10% hypertonic sodium chloride in the treatment of congestive heart failure (CHF) with hyponatremia. Methods A total of 110 CHF patients with hyponatremia were enrolled in this study. On the basis of general treatment (rest, oxygen inhalation, cardioplegia, diuretic, vasodilator) and treatment of primary disease, And control group 50 cases for comparative analysis. The treatment group was given water treatment at the same time 10% sodium chloride treatment. Control group water but not sodium. Observed before and after treatment, serum sodium concentration, sodium and heart function to improve time. Results The serum sodium concentrations in the treatment group and the control group before treatment were (12 7.13 ± 4.99) mmol / L, (12 6 .02 ± 5 .98) mmol / L (P> 0.05) (137.38 ± 4.54 mmol / L, (12.436 ± 8.72) mmol / L, P <0.01). The treatment group and the control group after treatment, serum sodium improvement were (3.72 ± 2.55) days and (10.72 ± 5.28) days (P <0.01). The heart function improvement time was (6.40 ± 3.10) days, (10.58 ± 4.21) days (P <0.01). Conclusions 10% sodium chloride is safe and effective in CHF hyponatremia and hyponatremia and cardiac function can be improved in the short term.