论文部分内容阅读
维生素A及某些天然的和人工的同类物具有抗肿瘤作用。其抗癌机制有几种可能:通过控制上皮细胞的分化而抑制上皮组织癌变;促进免疫作用从而间接抑制癌变,即由于它们的佐剂样的作用而增强宿主抗肿瘤的细胞免疫效应。视黄醛软脂酸酯和视黄酸(维生素 A 酸)可促进皮肤移植物的排斥,表明它们具有刺激细胞免疫的作用。作者曾证明视黄酸在非毒性剂量范围内可刺激细胞介导的细胞毒性效应(CMC 效应),而高剂量则抑制此种效应并出现全身中毒症状。本研究又证明,持续5天至3个月给予视黄酸,对
Vitamin A and certain natural and artificial congeners have an anti-tumor effect. Its anti-cancer mechanism has several possibilities: inhibit epithelial tissue canceration by controlling the differentiation of epithelial cells; promote immunity to indirectly inhibit canceration, ie, enhance their anti-tumor cellular immune effects due to their adjuvant-like effects. Retinol palmitate and retinoic acid (vitamin A acid) promote skin graft rejection, indicating that they have the effect of stimulating cellular immunity. The authors have demonstrated that retinoic acid stimulates cell-mediated cytotoxicity (CMC effects) within a non-toxic dose range, while high doses suppress this effect and show symptoms of systemic toxicity. This study also demonstrated that retinoic acid was administered for 5 days to 3 months.