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头颈部晚期癌的恶臭,对患者及其周围的人影响很大。过去认为是由于肿瘤坏死合并绿脓杆菌感染,近来证明是厌氧菌感染所致。处理此种感染,除氯霉素外,其它抗生素皆无效。但氯霉素影响造血机能,不利于晚期癌恶病质患者使用。本文对喉癌、甲状腺癌、舌癌及软骨肉瘤晚期有恶臭的4例患者,应用氯林可霉素(clindamycin,CLDM)和灭滴灵(metronidazole,MET)治疗,效果良好。 CLDM及MET联合使用比单独使用效果更好。CLDM用量为600～900mg/日,分4次;MET 250～500 mg/日,分2次投给。连续使用3～10天,恶臭消失即可停药。停药后若恶臭复发,可重复用药。这种间断给药法,可避免副作
The odor of advanced cancer of the head and neck has a great influence on the patient and the surrounding people. In the past, it was thought that tumor necrosis combined with Pseudomonas aeruginosa infection has recently been shown to be caused by an anaerobic infection. In addition to chloramphenicol, other antibiotics are not effective in the treatment of such infections. However, chloramphenicol affects hematopoietic function and is not beneficial to patients with advanced cancer cachexia. In this paper, clindamycin (CLDM) and metronidazole (MET) were used in 4 patients with malodor in the late stage of laryngeal cancer, thyroid cancer, tongue cancer, and chondrosarcoma with good results. The combined use of CLDM and MET is better than using it alone. The dose of CLDM was 600-900 mg/day in 4 divided doses; MET 250-500 mg/day was divided into 2 doses. Continuous use of 3 to 10 days, the odor disappears to stop the drug. If odor relapses after discontinuation of medication, repeat the medication. This intermittent administration method can avoid side effects