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随机选择30例寻常性银屑病患者和10例正常人,以抗人T细胞表面抗原的单克隆抗体CD_3,CD_4和CD_8用间接免疫荧光法检测其外周血T细胞及其亚群。患者分成7组,进行期、静止期、退行期,点滴状型和斑块状型,受损面积不足10％和10％以上。每组10例。对照组为10例健康成人。结果表明:1.与对照组相比,各组外周血CD_3~+、CD_4~+和CD_8~+细胞百分率及CD_4~+/CD_8~+细胞比率未见明显差异(均P>0.05)。2.点滴状与斑块型组间及受损面积不足10％与10％以上组间的CD_3~+、CD_4~+和CD_8~+细胞百分率及CD_4~+/CD_8~+细胞比率未见明显差异(均P>0.05)。3.进行期和静止期组CD_4~+/CD_8~+细胞比率,经方差分析证实明显地低于退行期组(F=3.73 P<0.05)。结合该发现,就寻常性银屑病的发病机理进行了分析和讨论。
Thirty patients with psoriasis vulgaris and 10 normal controls were randomly selected. T cells and their subpopulations were detected by indirect immunofluorescence using monoclonal antibodies against human T cell surface antigen CD_3, CD_4 and CD_8. The patients were divided into 7 groups: stage, quiescence, degenerative stage, drip-like and plaque-type, with less than 10% and 10% of damaged area. 10 cases in each group. The control group was 10 healthy adults. The results showed that: 1. Compared with the control group, there was no significant difference in the percentage of CD_3 ~ +, CD_4 ~ + and CD_8 ~ + cells and the ratio of CD_4 ~ + / CD_8 ~ + cells in the peripheral blood of all the groups (all P> 0.05). The percentage of CD_3 ~ +, CD_4 ~ + and CD_8 ~ + cells and the percentage of CD_4 ~ + / CD_8 ~ + cells in the groups of less than 10% and less than 10% Difference (all P> 0.05). The proportion of CD_4 ~ + / CD_8 ~ + cells in the stage of quiescent and quiescent group was significantly lower than that in the group of degenerative stage by variance analysis (F = 3.73 P <0.05). Combined with this discovery, the pathogenesis of psoriasis vulgaris were analyzed and discussed.