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目的:优选七宝美髯胶囊中药材的最佳提取纯化工艺。方法:采用正交试验法,以提取液中二苯乙烯苷的含量以及总固体得率为指标,综合评分优选药材的提取与纯化工艺。结果:药材较优的提取工艺为加水6倍,提取3次,每次0.5 h,纯化工艺是将药液浓缩至相对密度1.05(60℃)、调整醇沉浓度为50%,醇沉后静置24 h,滤过,回收乙醇即可。结论:优选的提取纯化工艺各活性部位提取率高,操作简便,适用于生产。
Objective: To optimize the extraction and purification of Chinese herbal medicines from Qibao Meijie capsules. Methods: The orthogonal test was used to determine the content of stilbene glycoside in the extract and the total solid yield as the index. The comprehensive score was optimized to extract and purify the medicinal materials. Results: The optimal extraction process of medicinal materials was 6 times of water, 3 times of extraction, each time being 0.5 h. The purification process was to concentrate the liquid to a relative density of 1.05 (60 ℃), adjust the alcohol concentration to 50% Set 24 h, filtration, ethanol recovery can be. Conclusion: The optimal extraction and purification process of each active site extraction rate is high, easy to operate, suitable for production.