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目的:考察硫磺熏蒸党参对小鼠免疫功能的影响。方法:健康小鼠分为硫磺熏蒸党参高、中、低剂量组,低温真空养护党参组及空白对照组。小鼠连续灌胃给药10 d后,进行体质量变化、免疫器官指数、血细胞分析、巨噬细胞吞噬功能、细胞因子IL-2和IFN-γ含量的比较分析。结果:与空白对照组比较,中、高剂量硫磺熏蒸党参的水提液可抑制小鼠体质量增长;硫磺熏蒸党参高剂量组小鼠白细胞数显著增加;各给药组小鼠巨噬细胞吞噬功能显著提升,脾脏指数升高,细胞因子的产生增加,其中硫磺熏蒸党参中剂量组的脾脏指数和IFN-γ与空白对照组比较差异显著。结论:小鼠服用党参水提液对细胞免疫功能有一定促进作用;硫磺熏蒸党参的水提液与低温真空养护党参的水提液在实验期内对免疫功能的影响无统计学差异。然而服用硫磺熏蒸党参对小鼠的食欲和体质量增长会产生负面影响。
Objective: To investigate the effects of sulfur fumigation on immune function of mice. Methods: Healthy mice were divided into sulfur fumigation Codonopsis high, medium and low dose groups, low-temperature vacuum Codonopsis and blank control group. Mice were given gavage for 10 days. The changes of body weight, immune organ index, blood cell analysis, macrophage phagocytosis, cytokines IL-2 and IFN-γ were compared. Results: Compared with the blank control group, medium and high doses of sulfur fumigation Codonopsis water extract can inhibit the growth of body weight in mice; sulfur fumigation Codonopsis high-dose group of mice increased significantly the number of white blood cells; each group mice macrophage phagocytosis Function increased significantly, the spleen index increased, cytokine production increased, of which sulfur fumigation Codonopsis medium dose group spleen index and IFN-γ compared with the control group significant difference. CONCLUSION: The water extract of Codonopsis pilosula possesses a certain promotion effect on cellular immune function. The effect of sulfur fumigation on the immune function of Codonopsis pilosula extract and low temperature vacuum Codonopsis water extract during the experimental period has no significant difference. However, sulfur fumigation Codonopsis mice appetite and weight gain will have a negative impact.