论文部分内容阅读
目的研究当归抗肝纤维化的作用及机理。方法采用牛血清白蛋白 (BSA)致大鼠免疫损伤性肝纤维化模型 ,观察当归大、小剂量对其肝功能、超氧化物歧化酶 (SOD)、丙二醛 (MDA)及肝细胞膜功能的影响。结果当归尤其是小剂量当归具有明显提高肝细胞SOD、降低MDA的作用 (P <0 .0 5 ) ,并能提高肝细胞膜ATP酶 (ATPase)活性 (P <0 .0 5 )。结论提示当归具有明显的抗肝纤维化作用 ,且小剂量优于大剂量。
Objective To study the effect and mechanism of anti-liver fibrosis in Angelica sinensis. Methods The immune-induced hepatic fibrosis model induced by bovine serum albumin (BSA) was used to observe the liver function, superoxide dismutase (SOD), malondialdehyde (MDA) and hepatocyte membrane function in large and small doses of Angelica sinensis. Impact. RESULTS: Angelica sinensis, especially low-dose angelica sinensis, significantly increased hepatocyte SOD and decreased MDA (P < 0.05), and increased hepatic cell membrane ATPase (ATPase) activity (P <0.05). The conclusion suggests that Angelica sinensis has obvious anti-hepatic fibrosis effect, and small doses are superior to large doses.