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溶菌酶是细胞溶酶体中的一种酶,存在于许多组织和分泌物中,也存在于血液的有形成份中。作者用正常人作对照,证明血清溶菌酶水平与局限性肠炎病变的活动性有显著的相互关系。测定每组血清溶菌酶的平均浓度如下:对照组8.8±0.4,活动性的局限性肠炎组20.8±0.8,非活动性的局限性肠炎组10.4±0.7微克/毫升。在活动性的局限性肠炎组中,血清溶菌酶平均浓度与病变活动度的关系如下:轻度发作,15.6±0.8;中度发作,20±0.8,重度发作,25±1.7微克/毫升。对血清溶菌酶的研究表明,非活动性的局限性肠炎和正常人的血清溶菌酶平均水平仅有细微的差异,这是没有临床意义的。血清溶菌酶的重要意义在于它可作为判断局限性肠炎活动性的一个有用的指标,并且有助于判断临床过程的严重程度和反映治疗的反应。临床上重度的局限性肠炎患者的血清溶菌酶是倾向于高水平的,以此可以提示病变并非轻度活动或缓
Lysozyme is an enzyme in the cell lysosome, present in many tissues and secretions, and also in the visible components of the blood. The authors used normal controls as controls, demonstrating a significant correlation between serum lysozyme levels and the activity of localized enteritis lesions. The mean concentrations of lysozyme in each group were determined as follows: control group 8.8 ± 0.4, active localized enteritis group 20.8 ± 0.8, and inactive localized enterocolitis group 10.4 ± 0.7 μg / mL. In the active localized enteritis group, the mean serum lysozyme concentration was related to the degree of lesion activity as follows: mild attack, 15.6 ± 0.8; moderate attack, 20 ± 0.8, severe attack, 25 ± 1.7 μg / mL. Studies of serum lysozyme have shown that there is only a slight difference in the average level of serum lysozyme between inactive enteropathy and normal, which is of no clinical significance. The significance of serum lysozyme is that it can be used as a useful indicator to determine the activity of localized enteritis and to help determine the severity of the clinical course and reflect the response to treatment. Serum lysozyme in patients with clinically severe localized enteritis tends to be at a high level, suggesting that the lesion is not mildly active or slow