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目的优选黄参膏的最佳提取工艺。方法选择提取次数、提取时间、溶剂倍数为考察因素,各因素均选3个水平,以L9(34)正交试验法制备黄参膏,以体外人胃癌细胞凋亡指数作为工艺考察指标,优选黄参膏的最佳提取工艺。结果最佳提取工艺为加8倍药材量水,煮提2次,每次煎煮1h。结论优选得到的提取工艺稳定、可行,进一步验证诱导胃癌细胞凋亡是黄参膏抗癌作用的机制之一。
Objective To optimize the best extraction process of yellow ginseng cream. Methods The number of extraction, extraction time and solvent multiples were investigated. The factors were all selected at three levels. The yellow ginseng extract was prepared by L9 (34) orthogonal test. The best extraction process of yellow ginseng cream. Results The best extraction process is to add 8 times the amount of medicine water, cooking 2 times, each boiling 1h. Conclusion The optimized extraction process is stable and feasible. It is further verified that induction of apoptosis in gastric cancer cells is one of the mechanisms of anti-cancer effect of Huangsong Ointment.