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本文报道了2-羧基色酮的7-取代衍生物Ⅰ_(1～10)和Ⅱ_(1～8)的合成,以Ⅳ为原料与相应的氯代物反应,可得相应的Ⅰ_(1～10)和Ⅱ_(1～20)以Ⅰ_6为原料与各种不同胺类反应则可得Ⅱ_(3～80) Ⅰ_6和Ⅱ_1具有类似色甘酸钠(DSCG)对被动皮肤过敏(PCA)的保获作用,Ⅰ_9具有较强的体外抑制血小板聚集的作用。
This paper reports the synthesis of 2-carboxychromone 7-substituted derivatives Ⅰ_ (1-10) and Ⅱ_ (1-8). The reaction of Ⅳ with the corresponding chlorides gives the corresponding I_ (1-10) ) And Ⅱ_ (1 ~ 20) with Ⅰ_6 as raw materials and various amines can be obtained Ⅱ_ (3 ~ 80) Ⅰ_6 and Ⅱ_1 similar cromolyn sodium (DSCG) on passive skin allergy (PCA) , Ⅰ_9 has a strong inhibitory effect on platelet aggregation in vitro.