25年前,Gregory和Tracy从猪的窦粘膜中识别了两种70个肽的胃泌素Ⅰ和Ⅱ。1955年zollinger和Ellison发表了两例暴发性消化性溃疡病的临床资料。他们发现这两名病人都有一个胰腺非β细胞瘤—一例于死后尸检时发现,另一例在剖腹术中发现。且该胰腺瘤含有与胰高糖素相似的,能升高血糖的异常蛋白。Zollinger和Ellison认为,胃的腺体受到了一种激素性的或化学性的刺激。他们提出,凡控制不良的或不典型的原发性消 Twenty-five years ago, Gregory and Tracy identified two 70 peptides of gastrin I and II from pig sinus mucosa. Zollinger and Ellison published two clinical data on fulminant peptic ulcer disease in 1955. They found that both patients had a non-beta cell tumor of the pancreas—one case was found at postmortem autopsy and the other was found during laparotomy. And this pancreatic tumor contains an abnormal protein that can increase blood sugar similar to glucagon. Zollinger and Ellison believe that the glands of the stomach are subjected to a hormonal or chemical stimulus. They propose that any poorly controlled or untypical primary consumer