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目的研究哮喘患者完全控制后继续表面吸入激素长期治疗的临床治疗措施。方法收集我院哮喘专科门诊符合标准的轻、中度哮喘完全控制患者38例,随机分为A、B两组继续治疗。监测呼气流速峰值占预计值百分比(PEF%)、诱导痰嗜酸性粒细胞直接计数EOS(%)及IL-5浓度水平,比较两组不同治疗方案的疗效。结果两组38例患者经规范治疗后,PEF均控制稳定,两组间的PEF%比较差异无统计学意义(P>0.05)。两组的痰液EOS、IL-5在基线期与各个治疗周期结束后差异也无统计学意义。结论两种治疗方案对改善哮喘完全控制患者的PEF%、EOS计数和IL-5浓度改善水平没有明显差异。
Objective To study the clinical treatment of long-term inhaled steroids after complete control of asthma patients. Methods Thirty-eight patients with complete or partial control of mild and moderate asthma were collected from asthma specialist clinics in our hospital and were randomly divided into A and B groups for further treatment. The peak values of predicted expiratory flow rate (PEF%), induced sputum eosinophils direct count EOS (%) and IL-5 concentration were monitored. The curative effect of different treatment regimens was compared. Results After treatment of 38 patients in both groups, the control of PEF was stable. There was no significant difference in PEF% between the two groups (P> 0.05). Sputum EOS, IL-5 in both groups at baseline and after the end of each treatment period, the difference was not statistically significant. Conclusions There is no significant difference between the two treatment regimens in improving PEF%, EOS and IL-5 levels in patients with complete asthma control.