论文部分内容阅读
各种物理化学因子、致病微生物均可导致染色体畸变和姐妹染色单体交换(SCE)的频率增加,但结核杆菌引起染色体损伤的资料很少。作者在未治结核病患者中测定了染色体畸变和SCE的频率,以估价结核杆菌对染色体的影响。经痰和X线检查确诊的未治结核病患者95例,年龄14～60岁,平均26.3岁,男性44例,女性51例。将病人分为五组,1、2、3、4组每组20例,5组15例。选择年龄、性格匹配的健康人为对照组。未治结核病组染色体畸变频率明显高于对照组(P<0.001)。前者畸变中期分裂相为1～9,平均4.2;后者畸变中期相1～5,平均2.45。未治结核病组染色体断裂总数为96,平均1.01:对照组为14,平均
Various physical and chemical factors, pathogenic microorganisms can cause chromosomal aberrations and sister chromatid exchange (SCE) increased frequency, but M. tuberculosis chromosomal damage caused by very little information. The authors examined the frequency of chromosomal aberrations and SCE in patients with untreated tuberculosis to assess the effects of Mycobacterium tuberculosis on the chromosome. Ninety-five cases of untreated tuberculosis diagnosed by sputum and X-ray were aged 14-60 years (mean 26.3 years), 44 were males and 51 were females. The patients were divided into five groups, 1, 2, 3, 4 groups of 20 cases, 5 groups of 15 cases. Select the age, character match the healthy control group. The frequency of chromosomal aberrations in the untreated TB group was significantly higher than that in the control group (P <0.001). The former distorted metaphase was 1 to 9 with an average of 4.2; the latter had a metaphase of 1 to 5 with an average of 2.45. The total number of chromosome rupture in the untreated TB group was 96, with an average of 1.01: the control group was 14, mean