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目的探讨静脉滴注头孢曲松后用酒精擦拭皮肤所致双硫仑样反应的发生机制、处理方法和预防措施,以及双硫仑样反应与过敏反应和急性冠脉综合征的区别要点。方法对1例静脉滴注头孢曲松后用酒精擦拭皮肤所致的双硫仑样反应的临床表现、治疗过程和救护措施进行回顾性分析,提示临床在执行药物治疗时,除询问患者过敏史外,还应特别询问患者的饮酒史。结果本例患者治疗及时,护理得当,恢复良好,2h后不适症状缓解。结论使用头孢曲松等抗生素时应禁止饮酒,禁止酒精擦浴和皮肤接触酒精,临床药师对患者进行用药指导,对临床医生进行专业知识讲座,避免发生双硫仑样反应,保证患者的用药安全。
Objective To investigate the mechanism, treatment and preventive measures of disulfiram-like reaction induced by ethanol wiping the skin after intravenous infusion of ceftriaxone, and the main points of difference between disulfiram-like reaction and allergic reaction and acute coronary syndrome. Methods A retrospective analysis of the clinical manifestation, course of treatment and ambulance measures of one case of disulfiram-like reaction caused by ethanol wiping the skin after intravenous infusion of ceftriaxone showed that in clinical practice, In addition, patients should also be asked in particular the history of drinking. Results The patients treated promptly, properly nursing, recovery is good, 2h after the discomfort relief. Conclusions When using antibiotics such as ceftriaxone, alcohol should be banned, alcohol rubbing bath and skin contact with alcohol should be banned, clinical pharmacists should guide the patients and provide professional knowledge to clinicians to avoid disulfiram-like reactions and ensure the safety of patients .