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(S)-3,5-bistrifluoromethylphenyl ethanol is a key chiral intermediate for the synthesis of NK-1 receptor antagonists. Enantioselective synthesis of (S)-3,5-bistrifluoromethylphenyl ethanol was successfully performed in high enantiomeric excess (e.e.) through asymmetric reduction of 3,5-bis(trifluoromethyl) acetophenone catalyzed by Candida tropicalis 104 cells. The influence of some key reaction parameters such as substrate concentration, co-substrate and its concentration, biomass and reaction time was examined, respectively. The results showed that these factors obviously influence the yield, but the optical purity of the prepared product remains intact. The opti-mum conditions for the preparation of (S)-3,5-bistrifluoromethylphenyl ethanol were found to be as follows: sub-strate concentration 50 mmol?L?1; 50 g·L-1 of maltose as co-substrate; wet cell concentration 300 g·L-1; reaction for 30 h. Under above optimal conditions, the maximum yield for (S)-3,5-bistrifluoromethylphenyl ethanol reached 70.3% with 100% of product e.e.
(S) -3,5-bistrifluoromethylphenyl ethanol is a key chiral intermediate for the synthesis of NK-1 receptor antagonists. Enantioselective synthesis of (S) -3,5-bistrifluoromethylphenyl ethanol was successfully performed in high enantiomeric excess (ee) through asymmetric The influence of some key reaction parameters such as substrate concentration, co-substrate and its concentration, biomass and reaction time was examined, respectively. The influence of some key reaction parameters such as substrate concentration, co These factors obviously affect the yield, but the optical purity of the prepared product remains intact. The opti-mum conditions for the preparation of (S) -3,5-bistrifluoromethylphenyl ethanol were found to as follows: sub-strate concentration 50 mmol L -1; 50 g · L- 1 of maltose as co-substrate; wet cell concentration of 300 g · L -1; reaction for 30 h. Under above optimal conditions, bistrifluoromethylphenyl e thanol reached 70.3% with 100% of product e.e.