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观察狗心脏停搏30分钟后的心肺复苏效果,以10%氯化钾溶液静脉注射使实验狗心脏停搏、呼吸停止30分钟后,分两组进行心肺复苏实验研究.实验狗每组5只.第一组采用常规法;第二组采用心肺转流(cardiopul-monary bypass,CPB)法.实验期间,定时对心电图、动脉压、静脉压、动脉血气和瞳孔进行监测.心肺骤停后60分钟检查最终复苏效果.结果第一组仅1只狗(20%)于第15分钟后恢复自主循环,瞳孔开始缩小,其余4只狗均未获复苏;第二组于2—3分钟后全部恢复自主循环(100%),瞳孔缩小.复苏30分钟后,其平均动脉压为8—14.0kPa,明显高于第一组(0—12.0kPa)(P<0.05),其静脉压为0.09—0.12kPa,明显低于第一组(0.14—0.24kPa)(P<0.01),PaCO_2为2.06—5.73kPa,明显低于第一组7.22—11.90kPa;PaO_2为21.70一59.81kPa,明显高于第一组(5.88—14.56kPa)(P<0.01).上述实验结果表明,心搏呼吸骤停30分钟后,以心肺转流法进行复苏可有效地恢复自主循环,并可能有益于脑复苏.从少量实验动物复苏效果提示,CPB法明显优于常规法.
Cardiopulmonary resuscitation (CPR) was observed 30 minutes after cardioplegia in dogs. Cardiopulmonary resuscitation (CPR) was performed in 10% potassium chloride solution intravenously to stop the heart of experimental dogs and resuscitation for 30 minutes. Five dogs . The first group used routine method and the second used cardiopulmonary bypass (CPB) method.Electrocardiogram, arterial pressure, venous pressure, arterial blood gas and pupil were monitored regularly during the experiment.After cardiopulmonary arrest 60 Minutes to check the final resuscitation effect.Results Only one dog (20%) in the first group recovered spontaneous circulation after 15 minutes, the pupil began to shrink, and the remaining four dogs were not recovered; the second group after 2-3 minutes Recovery of spontaneous circulation (100%), miosis .After 30 minutes of resuscitation, the mean arterial pressure was 8-14.0kPa, significantly higher than the first group (0-12.0kPa) (P <0.05), and its venous pressure was 0.09- 0.12kPa, significantly lower than the first group (0.14-0.24kPa) (P <0.01), PaCO_2 2.06-5.73kPa, significantly lower than the first group 7.22-11.90kPa; PaO_2 21.70-59.81kPa, significantly higher than the first group A group (5.88-14.56kPa) (P <0.01) .The above experimental results show that cardiac arrest after 30 minutes of resuscitation cardiopulmonary bypass Effectively restore spontaneous circulation, and may be beneficial for the brain to recover, suggesting that recovery from the effects of a small amount of experimental animals, CPB method is superior to conventional methods.