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目的探讨血清多肿瘤标志物蛋白芯片检测系统(C-12)检测结果对结直肠癌(CRC)的诊断价值。方法采用C-12对130例住院CRC患者(CRC组)和108例门诊体检人员(对照组)血清进行检测,分析C-12在两组人群之间、CRC不同TNM分期之间、C-12包含的12种肿瘤标志物之间、不同肿瘤标志物联合检测之间的阳性率差异。结果 CRC组C-12阳性率显著高于对照组(P<0.01),随CRC分期升高而上升(P<0.01),其中CEA、CA242、CA19-9阳性率显著高于其余9项肿瘤标志物(P<0.01),CEA联合CA242、CA19-9检测能提高敏感度,但它们之间联合检测或12项肿瘤标志物联合检测与单项肿瘤标志物CEA相比差异无显著性(P>0.05)。结论 C-12有助于CRC诊断,临床分期越晚诊断价值越高,其中CEA、CA242、CA19-9的诊断价值优于其余9项肿瘤标志物,多肿瘤标志物联合检测能提高检测敏感度,但并不显著优于单项肿瘤标志物CEA。
Objective To investigate the diagnostic value of serum multiple tumor marker protein chip detection system (C-12) in colorectal cancer (CRC). Methods Serum samples from 130 hospitalized CRC patients (CRC group) and 108 outpatients (control group) were detected by C-12. The differences of C-12 between two groups of patients, between different TNM stages of CRC, between C-12 Including the 12 kinds of tumor markers, the detection of different tumor markers between the positive rate differences. Results The positive rate of C-12 in CRC group was significantly higher than that in control group (P <0.01), and increased with the rise of CRC stage (P <0.01). The positive rates of CEA, CA242 and CA19-9 were significantly higher than those of the other 9 tumor markers (P <0.01). CEA combined with CA242 and CA19-9 could improve the sensitivity. However, there was no significant difference between the combined detection of CEA and the detection of 12 tumor markers and the single tumor marker CEA (P> 0.05 ). Conclusions C-12 is helpful for the diagnosis of CRC. The later the clinical stage, the higher the diagnostic value is, the diagnostic value of CEA, CA242 and CA19-9 is better than the other nine tumor markers. Combined detection of multiple tumor markers can improve the detection sensitivity , But not significantly better than the single tumor marker CEA.