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EBV与许多恶性疾病包括霍奇金病、伯基特淋巴瘤、鼻咽癌等恶性肿瘤发病有关人类B淋巴细胞是EBV天然宿主,其在宿主细胞中的生活周期分为潜伏感染和裂解感染。EBV潜伏感染时,为逃避宿主细胞的免疫杀伤,仅表达少量基因产物。而在外界条件如化学、物理或宿主细胞分化的刺激下,EBV可由潜伏感染进入到裂解复制(Lytic Replication)感染周期,促进病毒在宿主细胞中播散。根据EBV裂解复制产物出现的时间顺序可将裂解复制周期分为裂解复制立即早期、早期和晚期。1 EBV裂解复制不同时期产物的调控作用
EBV is associated with a number of malignant diseases including Hodgkin’s disease, Burkitt’s lymphoma, and nasopharyngeal carcinomas. Human B lymphocytes are natural EBV hosts whose life cycle in host cells is divided into latent infections and lytic infections. EBV latent infection, in order to escape the host cell immune killing, expressing only a small amount of gene products. In the external environment, such as chemical, physical or host cell differentiation stimulation, EBV can be latent infection into the Lytic Replication infection cycle, promote the virus in the host cell dissemination. According to the chronological order in which EBV cleavage products appear, the cleavage replication cycle can be divided into early, early, and late stages of lytic replication. 1 EBV Lysing Replication Regulation of Products at Different Stages