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目的探讨PCNA和Ki-67的表达与胃肠道间质瘤(GIST)临床病理学特征的关系及其相关性。方法应用免疫组化SP法观察40例胃肠道间质瘤中PCNA和Ki-67的表达。结果40例GIST中有26例表达PCNA,24例表达Ki-67,阳性表达率分别为65.0%和60.0%。PCNA和Ki-67的表达与组织学分级有关(P<0.01),两者的表达具有正相关性(r=0.471)。结论PCNA和Ki-67在胃肠道间质瘤的发生、发展中发挥作用,两者可作为判断GIST良恶性的客观指标。
Objective To investigate the relationship between the expression of PCNA and Ki-67 and clinicopathological features of gastrointestinal stromal tumors (GIST). Methods The expression of PCNA and Ki-67 in 40 cases of gastrointestinal stromal tumors were observed by immunohistochemical SP method. Results In 40 cases of GIST, 26 cases expressed PCNA and 24 cases expressed Ki-67. The positive rates were 65.0% and 60.0% respectively. The expression of PCNA and Ki-67 was correlated with the histological grade (P <0.01), and the positive correlation was found between them (r = 0.471). Conclusions PCNA and Ki-67 play a role in the occurrence and development of gastrointestinal stromal tumors, both of which can be used as objective indicators to judge the benign and malignant GIST.