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在催醒安的邻位和对位异构体及其同系物的苯坏上引入烷基后,可以增强抑制胆碱酯酶的活性,我们乃进一步在催醒安及其同系物的苯环不同位置上引入叔丁基,合成了一系列二甲氨基甲酸-[3-(烷氨基)烷氧基-4(5)-叔丁基]苯酯(Ⅰ_(1～13)和Ⅱ_(1～5))(表2),以探索对活性的影响。
The introduction of an alkyl group on the phenyl ring in the ortho-position and the para-isomer and its homologues of anoxene enhances the activity of cholinesterase inhibition. We further further investigated the effects of anoxene and its homologues on the benzene ring A series of dimethylcarbamates - [3- (alkylamino) alkoxy-4 (5) -tert-butyl] phenyl ester (Ⅰ_1-13) and Ⅱ_ ~ 5)) (Table 2) to explore the effect on activity.