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目的 :探讨颈动脉粥样硬化斑块形成后血管内膜中PCNA的表达。方法 :我院2006年8月~2013年6月CEA术后血管内膜80例为实验组,对照组选取骨肿瘤截肢正常动脉血管内膜标本10例,对两组进行免疫组织化学染色,通过对阳性细胞数、着色强弱等指标的观察,对比两组间PCNA表达的阳性分级。结果 :实验组与对照组相比较,两组PCNA阳性分级对比具有显著性差异。结论 :PCNA的表达增强在颈动脉粥样硬化斑块形成过程中可促进血管平滑肌细胞增殖,为粥样硬化斑块形成的重要影响因子。
Objective: To investigate the expression of PCNA in intima after carotid atherosclerotic plaque formation. Methods: From August 2006 to June 2013, 80 cases of endometriosis after CEA were selected as the experimental group, 10 cases of normal intimal vascular samples of the bone tumor were selected as the control group, immunohistochemical staining was performed on the two groups The number of positive cells, the strength of the staining and other indicators of observation, comparing the positive expression of PCNA between the two groups. Results: Compared with the control group, there was a significant difference between the two groups in PCNA positive grading. Conclusion: The enhanced expression of PCNA can promote the proliferation of vascular smooth muscle cells during the formation of carotid atherosclerosis plaque, which is an important factor for the formation of atherosclerotic plaque.