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目的通过对IFN-α和胰岛素相互作用的研究,为临床合理用药、提高乙肝伴发/并发糖尿病患者抗病毒治疗效果提供依据,以寻求最佳的治疗方案。方法选取2012年1月-2014年7月医院收治的慢性乙型肝炎患者136例。随机分为对照组与试验组各68例。试验组采用IFN-α正规抗病毒治疗,同时应用胰岛素进行个体化控制血糖;对照组采用IFN-α正规抗病毒治疗,同时应用非胰岛素类降糖药进行个体化控制血糖。2组患者均进行48周的治疗,疗程结束后随访24周。观察患者的临床各项指标变化情况。结果试验组总有效率94.1%明显高于对照组的73.5%,差异有统计学意义(P<0.05)。试验组治疗后ALT、AST、ALB等肝功能指标均低于对照组,差异有统计学意义(P<0.05)。结论对于慢性乙型肝炎合并糖尿病患者而言,应用IFN-α正规抗病毒治疗,同时应用胰岛素进行个体化控制血糖,治疗效果显著,具有治疗有效率高、病毒抑制强的优点,值得临床推广应用。
OBJECTIVE: To study the interaction between IFN-α and insulin to provide the basis for clinical rational use of drugs and to improve the antiviral effect of hepatitis B patients with concurrent diabetes mellitus in order to seek the best treatment plan. Methods 136 patients with chronic hepatitis B admitted to our hospital from January 2012 to July 2014 were selected. Randomly divided into control group and experimental group of 68 cases. The experimental group was treated with IFN-α regular antiviral therapy and insulin was used to control blood glucose individually. The control group was treated with IFN-α regular antiviral therapy, and the non-insulin-type hypoglycemic agents were used to control blood glucose individually. Two groups of patients were treated for 48 weeks, followed up for 24 weeks after the end of treatment. Observe the changes of clinical indicators of patients. Results The total effective rate was 94.1% in the experimental group was significantly higher than 73.5% in the control group, the difference was statistically significant (P <0.05). The liver function indexes of ALT, AST and ALB in the experimental group after treatment were lower than those in the control group, with significant difference (P <0.05). Conclusion For patients with chronic hepatitis B and diabetes mellitus, the application of IFN-α regular antiviral therapy combined with insulin in the individual control of blood glucose has significant therapeutic effect, which has the advantages of high treatment efficiency and strong virus inhibition, and is worthy of clinical promotion and application .