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PLC/PRF/5细胞系又称Alexander细胞系,是一株能稳定持续产生HB_sAg的人肝癌细胞株。虽然国内外曾先后自肝癌组织建成不少细胞株,但能有乙型肝炎病毒抗原表达者仅有本株,Mahlavu株(由Prozesky 1973年建立)和Aden建立的另一株;而其中以PLC/PRF/5(以下简称PLC)产生HB_sAg最稳定,量最多,研究最广。自从1976年Macnab报道以来,PLC已成为国际上研究乙型肝炎病毒,乙肝病毒与肝癌关系的一个重要实验模型。近二、三年
PLC / PRF / 5 cell line, also known as Alexander cell line, is a stable and continuous production of human hepatocellular carcinoma cell line HB_sAg. Although many cell strains have been constructed from hepatocellular carcinoma both at home and abroad, only one strain of Hepatitis B virus antigen can be expressed, the Mahlavu strain (established by Prozesky in 1973) and another strain established by Aden; among them, PLC / PRF / 5 (hereinafter referred to as PLC) produce the most stable HB_sAg, the largest amount, the most widely studied. Since Macnab reported in 1976, PLC has become an international experimental model for studying the relationship between hepatitis B virus and hepatitis B virus. Nearly two or three years