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目的:探讨发生于胃的胃肠间质瘤(GIST)外科治疗的方法。方法:对1995年8月-2005年8月收治的经手术病理证实的19例胃GIST进行回顾性研究。结果:19例患者中,肿瘤位于贲门胃底区7例,胃体9例,胃窦3例。肿瘤最小2cm,最大25cm,中位大小6cm。胃周淋巴结转移1例。手术行胃楔形切除11例,近端胃大部切除5例,远端胃大部切除3例,其中联合脏器切除3例。查免疫组织化学CD117阳性16例,CD34阳性17例。术后随诊5例复发转移。结论:胃GIST治疗以手术为主,术中应根据肿瘤大小、部位、有无外侵及淋巴结转移决定手术范围,切除在于完全而不在于大范围清扫。
Objective: To investigate the surgical treatment of gastric gastrointestinal stromal tumors (GIST). Methods: A retrospective study was performed on 19 patients with gastric GIST confirmed by surgery and pathology from August 1995 to August 2005. Results: Of the 19 patients, 7 were located in the fundus of gastric cardia, 9 in gastric and 3 in gastric antrum. The smallest tumor 2cm, the largest 25cm, the median size of 6cm. 1 case of gastric lymph node metastasis. There were 11 cases of wedge resection, 5 cases of proximal gastrectomy, 3 cases of distal gastrectomy, and 3 cases of resection of organ. Immunohistochemical CD117 positive 16 cases, CD34 positive in 17 cases. Postoperative follow-up of 5 cases of recurrence and metastasis. Conclusion: The operation of gastric GIST is mainly surgery. The scope of operation should be decided according to tumor size, site, presence or absence of invasion and lymph node metastasis. The resection is entirely but not extensive.