论文部分内容阅读
一些骨髓增殖性疾病(MPD)病例有可能转化为急性髓系白血病(AML),但是迄今尚未观察到体内MPD细胞转化为AML细胞的分化过程。本研究旨在揭示这一分化过程。采用流式细胞术分析了2例MPD短期内转为AML患者骨髓分化细胞的免疫表型特征。研究结果表明,体内发展相对缓慢的MPD增殖细胞演化为迅速扩增的急性白血病细胞时,存在不同分化阶段的亚克隆。结论:了解MPD急变过程将有助于早期诊断和治疗MPD转化的急性白血病。
Some cases of myeloproliferative disease (MPD) are likely to convert to acute myeloid leukemia (AML), but so far no changes in the differentiation of MPD cells into AML cells have been observed. This study aims to reveal this process of differentiation. Flow cytometry was used to analyze the immunophenotypic features of 2 myeloid differentiated cells from 2 MPD patients who transfered to AML in short term. The results show that subpopulations of different differentiation stages exist when rapidly proliferating acute leukemia cells evolve from MPD proliferating cells that develop relatively slowly in vivo. Conclusion: To understand the MPD emergency process will be helpful for the early diagnosis and treatment of MPD-transformed acute leukemia.