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目的探讨系统性红斑狼疮(SLE)合并妊娠高血压(PIH)患者的临床治疗方法及疗效。方法选取1999年1月至2015年12月惠州市第三人民医院收治的30例SLE合并PIH患者作为研究对象,按照随机数字表法将其分为试验组和对照组,各15例。对照组患者给予解痉、降压、镇静等常规对症治疗,试验组患者在对照组基础上采用激素进行治疗,比较两组患者的临床疗效及母婴结局。结果试验组患者治疗的总有效率明显高于对照组,剖宫产率、产后出血率、术口愈合不良率、胎儿窘迫及新生儿窒息率均明显低于对照组,差异均有统计学意义(均P<0.05)。结论在解痉降压适当镇静、有指征有条件扩容利尿基础上采用激素治疗SLE合并PIH,可明显提高临床疗效,改善母婴结局,减少狼疮危像发生,具有重要临床意义。
Objective To investigate the clinical treatment and efficacy of systemic lupus erythematosus (SLE) complicated with pregnancy-induced hypertension (PIH). Methods Thirty SLE patients with PIH admitted from the Third People ’s Hospital of Huizhou City from January 1999 to December 2015 were selected as the research objects. According to the random number table, they were divided into experimental group and control group, with 15 cases in each group. Control group patients given antispasmodic, antihypertensive, sedative and other conventional symptomatic treatment, the experimental group of patients in the control group based on the use of hormones for treatment, the two groups of patients were compared the clinical efficacy and maternal and infant outcomes. Results The total effective rate of treatment in experimental group was significantly higher than that in control group. The rate of cesarean section, postpartum hemorrhage rate, rate of non-performing surgery, fetal distress and neonatal asphyxia were significantly lower than those in control group (All P <0.05). Conclusions In spasmodic and antihypertensive appropriate sedation, indications of conditional diuresis based on the use of hormone therapy combined with PIH SLE, can significantly improve the clinical efficacy, improve maternal and infant outcomes, reduce the occurrence of lupus crisis, has important clinical significance.