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目的观察鸦胆子油乳剂联合白细胞介素-2胸腔内注射治疗肺癌胸水的疗效和不良反应。方法对48例肺癌所致恶性胸腔积液患者采用胸腔放置引流管放净胸水或胸腔排净胸水后,分为二组,每组24例,联合用药组胸腔内每次注入鸦胆子油乳剂80～100mL,白细胞介素-2300～500万单位,单药组胸腔内注入鸦胆子油乳剂80～100mL,5～7d一次,最多4次为1个疗程,1个月后观察疗效、生活质量和不良反应。结果联合用药组治疗肺癌胸水的有效率为91.67%(22/24),不良反应为发热(<38.5℃)19例,胃肠道反应1例,胸痛3例。单药组有效率为58.33%(14/24),不良反应为发热(<38.5℃)2例,胃肠道反应2例,胸痛1例。结论鸦胆子油乳剂联合白细胞介素-2治疗肺癌胸水比单用鸦胆子油乳剂近期疗效、生活质量明显提高(P<0.05),不良反应给予对症处理后很快缓解,值得进一步推广使用。
Objective To observe the efficacy and adverse reactions of Brucea javanica oil emulsion combined with interleukin-2 in the treatment of pleural effusion of lung cancer. Methods Forty-eight patients with malignant pleural effusion caused by lung cancer were divided into two groups (24 cases in each group) by using pleural drainage tube to drain the hydrothorax or pleural effusion. Each injection of Brucea javanica oil emulsion 80 ~ 100mL, interleukin -2300 ~ 5 million units, single drug group injection of Bruchs cholerae oil emulsion 80 ~ 100mL, 5 ~ 7d once, up to 4 times for a course of treatment, 1 month after the observation of efficacy, quality of life and Adverse reactions. Results The combined treatment group was 91.67% (22/24) for the treatment of pleural effusion of lung cancer, 19 for fever (<38.5 ℃), 1 for gastrointestinal reaction and 3 for chest pain. The effective rate was 58.33% (14/24) in monotherapy group, 2 in fever (<38.5 ℃), 2 in gastrointestinal tract and 1 in chest pain. Conclusion Brucea javanica oil combined with interleukin-2 treatment of lung cancer pleural effusion compared with single Brucea javanica oil emulsion short-term efficacy, quality of life was significantly improved (P lt; 0.05), adverse reactions given symptomatic treatment soon relief, worthy of further promotion and use.