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目的:探讨帕金森病(PD)患者的血浆尿酸(UA)水平,以及血浆UA水平与PD病程长短、病情程度分级间的关系。方法:采用回顾性调查,以2000至2008年在温州医学院附属第二医院神经内科住院治疗的汉族PD患者239例中符合入选标准的55例PD患者为PD组(排除可能影响尿酸代谢的其他疾病),另设对照组55例(非PD患者)。检测病例组和对照组的身高、体重、血浆UA等指标。结果:PD组血浆UA水平[(260±49)μmol·L~(-1)]明显低于对照组[(324±48)μmo·L~(-1)](P<0.001)。PD病情分级和病程长短与血浆UA水平均无明显相关。PD组体重指数(BMI)较对照组低,差异有统计学意义(P<0.05),但PD组BMI与UA两者间无明显相关性。结论:PD患者血浆UA水平降低,且低血浆UA水平存在于病程的各个阶段,提示低血浆UA水平可能与PD的发病机制关系密切。
Objective: To investigate the relationship between plasma uric acid (UA) and plasma UA levels in patients with Parkinson’s disease (PD) and the duration of PD and the severity of illness. Methods: A retrospective survey was conducted to investigate the prevalence of PD in patients with PD in our hospital from January 2000 to December 2008 in the Department of Neurology, Second Affiliated Hospital of Wenzhou Medical College. Among the PD patients treated with PD, Disease), the other 55 cases of control group (non-PD patients). The height, weight, plasma UA and other indexes of the case group and the control group were detected. Results: The level of plasma UA in PD group [(260 ± 49) μmol·L -1] was significantly lower than that in control group [(324 ± 48) μmo · L -1] (P <0.001). PD disease grade and duration of disease and plasma UA levels were not significantly correlated. The body mass index (BMI) in PD group was lower than that in control group (P <0.05), but there was no significant correlation between BMI and UA in PD group. Conclusions: The level of UA in plasma of patients with PD is decreased, and the level of low plasma UA is present in all stages of the course of disease, suggesting that low plasma UA levels may be closely related to the pathogenesis of PD.