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目的：观察甲状腺大部切除术与药物保守治疗甲状腺功能亢进的临床疗效。方法选取2009年4月-2013年4月医院收治的甲状腺功能亢进患者48例，随机分为 A 组和 B 组各24例，A 组采用甲状腺大部切除术进行治疗，B 组患者采用药物保守治疗。对比2组治疗效果。结果治疗后 A 组 FT3、FT4、TSH 等各项指标均显著低于B 组；A 组总有效率为95.8%显著高于 B 组的62.5%；A 组不良反应总发生率显著低于 B 组，比较差异均有统计学意义（P ﹤0.05）。结论甲状腺大部切除术治疗甲状腺功能亢进的疗效更加确切，不良反应发生率低，临床应用价值更高，应作为治疗甲状腺功能亢进的首选方法。“,”Objective To investigate and explore the clinical efficacy of subtotal thyroid resection and medicine in the treatment of hyperthyroidism. Methods 48 cases of patients with hyperthyroidism admitted by the hospital from April 2009 to April 2013 were selected as research subjects,and they were randomly divided into Group A(24 cases,subject to sub-total thyroid resection)and Group B(24 cases,conservative medicine treatment). The treatment effect of 2 groups were com-pared. Results After treatment,the indexes including FT3 ,FT4 and TSH and adverse reaction rates of Group A were signifi-cantly lower than that of Group B. The total effective rate(95. 8% )in group A after treatment was significantly higher than that on of group B(62. 5% ),the difference was statistically significant(P ﹤ 0. 05). Conclusion The efficacy of subtotal thy-roid resection is more accurate in the treatment of hyperthyroidism,which can reduce the incidence of adverse reactions,with higher clinical value,so it shall be regarded as preferred method for the treatment of hyperthyroidism.