进入体内的氨主要是在肝中解毒;所以肝脏病变时,解氨毒的功能减退。我们实验室曾以实验性肝硬变大鼠为研究对象,观察其氨耐量及氨解毒机制,发现:(1)此种病鼠的氨耐量较正常大鼠者显著下降;(2)L 精氨酸可在此种病鼠体内促进尿素的生成,从而具有显著的解氨毒作用;(3)L 谷氨酸虽可与氨结合以生成谷氨酰胺,但其在此种病鼠体内的解氨毒功效极为微小。 Into the body of ammonia is mainly detoxified in the liver; so liver lesions, detoxification of the drug dysfunction. Our laboratory used experimental liver cirrhosis rats as the research object, observing its mechanism of ammonia tolerance and ammonia detoxification, found: (1) the ammonia tolerance of these mice decreased significantly compared with normal rats; (2) L fine (3) L-glutamic acid can combine with ammonia to produce glutamine, but in this kind of diseased mice, the amino acid can promote the formation of urea in such diseased mice. Anti-ammonia poison effect is extremely small.