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目的 :观察高海拔地区 (海拔 2 2 60m)消化性溃疡患者血浆内皮素 (ET)水平的变化及与病情的关系 ;方法 :采用放射免疫分析法测定了 2 2例胃溃疡、1 5例十二指肠溃疡患者外周血ET -1水平 ,并与 2 0例健康人对照结果 :血浆ET -1水平 (ng/L) :胃溃疡组 ( 82 .50± 1 7.50 )ng/L ,十二指肠溃疡组 ( 81 .2 0± 1 8.3 2 )ng/L ,较对照组 ( 62 .54±5.82 )ng/L显著升高 (P <0 .0 1 ) ;胃溃疡组与十二指肠溃疡组比较差异无显著性 (P <0 .0 5) ;活动期胃和十二指肠溃疡组血浆ET水平均明显高于疤痕期 (P <0 .0 1 ) ;结论 :在高海拔地区血浆内皮素水平升高与消化性溃疡的发生密切相关 ,且血浆内皮素水平与病情的活动性有关。
Objective: To observe the changes of plasma endothelin (ET) levels and the relationship with the disease in patients with peptic ulcer at high altitude (2260 m above sea level). Methods: Twenty-two gastric ulcers were measured by radioimmunoassay The levels of ET-1 in peripheral blood of patients with duodenal ulcer were compared with those of 20 healthy subjects. The levels of plasma ET-1 (ng / L): gastric ulcer (82.5 ± 1.50) ng / L, L was significantly higher in the ulcer group than in the control group (62.54 ± 5.82 ng / L, P <0.01) There was no significant difference in intestinal ulcer group (P <0.05); ET level in active gastric and duodenal ulcer group was significantly higher than that in scar (P <0.01). Conclusion: At high altitude Regional plasma endothelin levels and the occurrence of peptic ulcer are closely related, and plasma endothelin levels and disease activity.