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于１９８９～１９９３年应用间接免疫荧光试验，对广安县流行性出血热（ＥＨＦ）疫区的１６３７只小哺乳动物和９４９名健康成人，分别进行了汉坦病毒（ＨＴＮＶ）抗原和抗体的连续五年调查。结果显示：（１）疫区的优势带毒动物为褐家鼠、四川短尾和黑线姬鼠。病毒的血清型属野鼠型。（２）５年中各年度各种动物的总带毒率和其中褐家鼠的带毒率均无显著差异（Ｐ＞０．１０和＞０．７０）。褐家鼠带毒率明显高于四川短尾（Ｐ＜０．００１），但与黑线姬鼠差别不显著（Ｐ＞０．３０）。（３）疫区健康成人血清抗体流行率无明显差异（Ｐ＞０．３０），但显著高于非疫区（Ｐ＜０．０５）。调查提示，５年中广安县ＥＨＦ疫区动物带毒率和人群血清抗体流行率保持稳定，与疫区人类ＥＨＦ持续发病一致。降低优势带毒动物的密度是灭鼠和控制ＥＨＦ流行的重点。
Indirect immunofluorescence assay was used to detect 1637 small mammals and 949 healthy adults in epidemic area of epidemic hemorrhagic fever (EHF) in Guang’an from 1989 to 1993. Five consecutive cases of Hantavirus (HTNV) antigen and antibody Annual survey. The results showed that: (1) The dominant poisonous animals in the infected area were Rattus norvegicus, Short-tailed Sichuan and Apodemus agrarius. The serotype of the virus is a wild mouse type. (2) There was no significant difference (P> 0.10 and> 0.70) of the total virulence rate of various animals and the virulence rate of Rattus norvegicus among the five years. The infection rate of brown rat was significantly higher than that of short tail of Sichuan (P <0.001), but not significantly different from that of Apodemus agrarius (P> 0.30). (3) There was no significant difference in the prevalence of serum antibodies among healthy adults (P> 0.30), but significantly higher than that in non-infected areas (P <0.05). The survey suggests that in 5 years Guang’an EHF prevalence of zoonotic and serogroup antibody prevalence remained stable, consistent with the continued incidence of human EHF in endemic areas. Decreasing the density of predominantly poisoned animals is the focus of deratization and control of the epidemic of EHF.