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肝脏结合蛋白(HBP)是肝细胞表面一种特异性非唾液酸基糖蛋白受体。由于HBP只存在于有功能肝细胞(包括再生肝细胞)的表面,因此,测定HBP能够间接了解功能性肝细胞的总数,即肝脏储备功能。病人与方法:本实验受试者30名,包括7名健康志愿者和23名有各种肝病的患者,其中男性23名,女性7名,年龄21～70岁(平均53.7岁)。每一受试者除检查HBP浓度外,还接受肝脏储备功能的经典指标的检查,井被注入人工合成的非唾液酸基糖蛋白的类同物及与HBP有特殊亲和力的放射配体——~(99m)锝标记的半乳糖基拟糖白蛋白(TcNGA),借助标准的核医学设备,经过对时间-活性数据的动力学分析,就可作出HBP总量的评价。
Liver-binding protein (HBP) is a specific non-sialic acid glycoprotein receptor on the surface of hepatocytes. Since HBP exists only on the surface of functional liver cells, including regenerative liver cells, determining HBP can indirectly understand the total number of functional liver cells, ie liver reserve function. PATIENTS AND METHODS: Thirty subjects, including seven healthy volunteers and 23 patients with various liver diseases, including 23 males and 7 females, aged 21 to 70 years (mean, 53.7 years) were included in this study. In addition to examining HBP concentrations, each subject was also tested for classical indicators of liver reserve function, injected with synthetic non-sialic acid glycoprotein congeners and radioserines with special affinity for HBP - The ~ (99m) technetium-labeled galactosylco-glycoprotein (TcNGA) can be used to assess the total amount of HBP with kinetic analysis of time-activity data using standard nuclear medicine equipment.