论文部分内容阅读
目的：研究细胞粘附分子（ＣＡＭｓ）在大肠癌浸润转移过程中的作用。方法：应用免疫组化ＬＳＡＢ法，检测ＣＡＭｓ家族ＣＥＡ，ＣＤ４４ｓ及ＣＤ４４ｖ９在正常肠上皮、大肠癌原发灶组织中表达的改变。结果：大肠癌细胞中ＣＡＭｓ的分布极性发生了明显改变；癌细胞的表达强度与正常肠上皮明显不同；在原发灶组中，ＣＥＡ和ＣＤ４４ｓ的表达呈显著正相关，ＣＤ４４ｖ９的表达与肿瘤的分化程度和Ｄｕｋｅｓ分期密切相关。结论：ＣＡＭｓ以分布极性的变动以及表达程度的改变影响着癌细胞的侵袭表型，在大肠癌浸润转移的过程中起着重要作用。ＣＤ４４ｓ和ＣＤ４４ｖ９有可能作为新的肿瘤标志物，用于癌症的辅助诊断或转移潜能的筛选。
Objective: To study the role of cell adhesion molecules (CAMs) in the invasion and metastasis of colorectal cancer. Methods: The expression of CEA, CD44s and CD44v9 in CAMs family was detected by immunohistochemical LSAB method in normal intestinal epithelium and colorectal cancer. Results: The distribution polarity of CAMs in colorectal cancer cells changed significantly; the expression intensity of cancer cells was significantly different from that of normal intestinal epithelium; in the primary focus group, there was a significant positive correlation between the expression of CEA and CD44s, and the expression of CD44v9 and tumors. The degree of differentiation is closely related to the Dukes stage. CONCLUSION: CAMs affect the invasive phenotype of cancer cells by changes in distribution polarity and the degree of expression, and play an important role in the process of infiltration and metastasis of colorectal cancer. CD44s and CD44v9 may be used as new tumor markers for the diagnosis of cancer or the screening of metastatic potential.