患儿,男,6岁,反复高热、闭汗、无牙6年。自生后第五天因不明原因高热就医,此后常因室温升高,衣着过多、哭吵而反复发热,体温39～40℃,使用青霉素,退热剂均无效,冷水擦浴能降温,退热时无汗。怕热,夏日怕阳光,每年4～8日昼夜卧于泥地度日,喜玩冷水,尿多、无汗。自幼无牙,生后6年从未剪过指(趾)甲。体查:身高98cm,体重30kg,身材均称,发育营养稍低,智力稍低下。全身皮肤菲薄,干燥,无汗毛,对疼 Children, male, 6 years old, repeated high fever, sweating, toothless 6 years. Since the fifth day after birth due to unknown causes of high fever for medical treatment, then often due to room temperature, excessive clothing, crying and repeated fever, body temperature 39 ~ 40 ℃, the use of penicillin, antipyretics are invalid, cold water bath can cool, Anti-perspiration when fever. Fear of heat, the sun is afraid of the summer, 4 to 8 days a year lying on the mud day and night, like to play cold water, urine and more, no sweat. No teeth since childhood, 6 years after birth never cut finger (toe) A. Physical examination: height 98cm, weight 30kg, body weight, slightly lower developmental nutrition, intelligence slightly lower. Body skin meager, dry, non-hairs, the pain