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目的 :分析CA12 5与食管贲门癌的关系及临床应用价值。方法 :应用酶联免疫吸附分析法(ELISA法 )测定 10 5例食管贲门癌患者和 73例健康成人血清CA12 5水平。结果 :①食管贲门癌患者的血清CA12 5水平显著高于健康成年人 (P <0 .0 0 1) ;②食管癌患者血清CA12 5水平在肿瘤不同分段间或大体病理类型间差异无显著性 ;③食管贲门癌患者的血清CA12 5水平与肿瘤大小、浸润深度、临床病理分期均呈正相关 ,而与鳞癌分化程度、有无转移无关 ,接受根治术患者的血清CA12 5水平显著低于接受剖胸探查术者 ,CA12 5阴性食管癌患者的肿瘤切除率 ( 94 6% )显著高于阳性患者 ( 70 6% ,P <0 0 2 )。结论 :血清CA12 5水平与食管贲门癌的生长浸润等生物学行为密切相关 ,较高的CA12 5水平提示肿瘤较大、浸润较深及分期较晚 ,且肿瘤可切除性明显降低 ,可为食管贲门癌的临床诊治提供有价值的信息
Objective: To analyze the relationship between CA12 5 and esophageal and cardiac cancer and its clinical value. Methods: Serum CA125 levels of 105 patients with esophageal and cardiac cancer and 73 healthy adults were determined by enzyme-linked immunosorbent assay (ELISA). Results: ① The level of serum CA12 5 in patients with esophageal and cardiac cancer was significantly higher than that in healthy adults (P0.01). ② The serum level of CA12 5 in patients with esophageal cancer was not significantly different between different segments of the tumor or general pathological types ; ③The level of serum CA12 5 in patients with esophageal and cardiac cancer was positively correlated with tumor size, depth of invasion and clinicopathological stage, but not with the degree of differentiation and metastasis of squamous cell carcinoma. The serum level of CA12 5 in patients undergoing radical operation was significantly lower than that of patients receiving radical operation Thoracotomy, CA12 5-negative patients with esophageal cancer tumor resection rate (94.6%) was significantly higher than the positive patients (70 6%, P <0 0 2). Conclusions: Serum CA12 5 is closely related to the biological behavior of esophageal and gastric cardia cancer. The higher CA12 5 level indicates that the tumor is larger, infiltrated deeper and staging is late, and the tumor resectability is significantly lower, which may be the result of esophagus Cardiac cancer clinical diagnosis and treatment to provide valuable information