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为探讨ｎｍ２３Ｈ１蛋白表达在食管癌中的临床意义，应用免疫组化ＳＰ法研究了６１例食管癌组织标本中ｎｍ２３Ｈ１蛋白表达与食管癌临床病理特征及预后的关系。ｎｍ２３Ｈ１蛋白阳性表达率为５４．１％（３３／６１），表达与性别、年龄、肿瘤部位、大小、病理类型及浸润程度无关。食管癌旁无淋巴结转移组ｎｍ２３Ｈ１阳性表达率为６１．５％（３２／５２），显著高于有转移组（１１．１％，１／９）。此外与术后肿瘤转移、复发有关，ｎｍ２３Ｈ１阳性表达组的术后生存时间明显长于ｎｍ２３Ｈ１阴性表达组（Ｐ＜０．０１）。结果表明：ｎｍ２３Ｈ１蛋白高表达对食管癌转移有一定的抑制作用，检测其表达有助于对食管癌生物学行为的了解和预后的判断。
To explore the clinical significance of nm23-H1 protein expression in esophageal cancer, immunohistochemical SP method was used to study the relationship between nm23-H1 protein expression and the clinicopathological features and prognosis of esophageal cancer in 61 specimens of esophageal cancer. The positive expression rate of nm23-H1 protein was 54.1% (33/61). The expression of nm23-H1 protein was not related to gender, age, tumor location, size, pathological type and infiltration degree. The positive expression rate of nm23-H1 in the group without lymph node metastasis was 61.5% (32/52), which was significantly higher than that in the metastatic group (11.1%, 1/9). In addition, it was associated with tumor metastasis and recurrence after surgery. The survival time of the nm23-H1 positive expression group was significantly longer than that of the nm23-H1 negative expression group (P<0.01). The results showed that the high expression of nm23H1 protein had a certain inhibitory effect on the metastasis of esophageal cancer. The detection of the expression of nm23H1 protein was helpful for understanding the biological behavior of esophageal cancer and judging the prognosis.