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幽门螺杆菌是一种广泛定植于人胃黏膜的革兰阴性菌，与慢性胃炎、消化性溃疡、胃癌的发生密切相关，其可通过多种毒力因子逃避宿主的免疫反应以造成慢性感染。自噬是真核生物进化过程中的高度保守过程，可清除细胞内的病原微生物，对维持机体内坏境起重要作用，并可通过溶酶体对受损、衰老的细胞器及生物大分子等进行吞噬降解，以维持细胞内环境稳定。幽门螺杆菌能够入侵胃上皮细胞和某些免疫细胞，诱导自噬的发生，并可在自噬体中复制后被清除。“,”Helicobacter pylori is one of the most common Gram -negative bacterial pathogens in gastric mucosa,and the infection causes a variety of gastric disorders ,including simple gastritis,peptic ulcer or gas-tric malignancies.It can use several mechanisms to evade both the innate and adaptive arms of the immune response,as a result,it can lead to chronic infection.Autophagy is a highly conserved process in eukaryotic evolution process,which can remove the intracellular pathogens and maintain cellular homeostasis through the degradation of cargo such as long-lived proteins and damaged organelles in the lysosomal .Helicobacter pylori can invade gastric epithelial cells and some immune cells and then induce autophagy ,and be eliminated after replication in autophagosomes.