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以牛磺胆酸钠诱发大鼠急性胰腺炎并发肺损伤模型，观察血小板活化因子拮抗剂ＢＮ５２０２１对肺病理形态、肺系数、血小板聚集率及肺血流量的影响，记录其大鼠存活率。结果表明，ＢＮ５２０２１治疗后，胰腺出血坏死程度减轻同时肺损伤显著改善，肺系数值、血小板聚集率显著低于急性胰腺炎非治疗组，肺相对血流量及组织灌注量显著高于急性胰腺炎非治疗组，大鼠存活率提高。提示内源性血小板活化因子通过增加肺血管通透性、影响肺血循环而介导急性胰腺炎大鼠肺损伤。
Rat model of acute pancreatitis induced by sodium taurocholate was induced by sodium taurocholate. The effects of platelet-activating factor antagonist BN52021 on pulmonary pathology, pulmonary coefficient, platelet aggregation rate and pulmonary blood flow were observed. The survival rate of rats was recorded. The results showed that after BN52021 treatment, the extent of hemorrhage and necrosis of the pancreas was alleviated and the lung injury was significantly improved. The pulmonary coefficient and platelet aggregation rate were significantly lower than those of the untreated acute pancreatitis group. The relative pulmonary blood flow and tissue perfusion were significantly higher than those of the acute pancreatitis Treatment group, rat survival rate increased. It is suggested that endogenous platelet activating factor mediates lung injury in rats with acute pancreatitis by increasing pulmonary vascular permeability and affecting pulmonary blood circulation.