一、前言 保幼激素类似物(Juvenile Hormone-734,简称JH-734)是昆虫咽侧体分泌的一种萜烯类化合物合成品。JH在昆虫界的生物效应已有大量研究。作者曾用[~3H]-JH-734在小鼠体内分布研究表明卵巢和子宫可能是JH的靶器官,用放射受体测定法发现兔和人卵巢胞浆液有能与[~3H]-JH-734高亲和力结合的JH受体蛋白存在,并初步测出人血清中有JH存在。但JH在高等哺乳动物有何生理或药理作用仍不清楚,本文依此目的进行初步研究。 I. Introduction Juvenile Hormone-734 (JH-734) is a synthetic product of terpene secreted by insect pharynx. The biological effects of JH in the insect community have been extensively studied. The authors have used [~ 3H] -JH-734 in vivo distribution studies in mice showed that the ovary and the uterus may be the target organ of JH, radioimmunoassay found that rabbit and human ovarian cytoplasm with [~ 3H] - JH-734 high affinity binding JH receptor protein exists, and preliminary determination of human serum JH presence. However, the physiological or pharmacological effects of JH in higher mammals remain unclear, and this study is based on this aim.