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目的通过对15例卵巢透明细胞癌(OCCC)患者的病理特征和预后因素分析,以期为OCCC的临床治疗提供参考。方法对2008年6月至2012年3月收治的15例OCCC患者的临床资料进行分析,对其病理特征和预后相关情况进行总结。结果 15例患者多以腹痛、腹胀、下腹部包块为主诉入院,共有13例(86.7%)出现腹痛,11例(73.3%)出现腹胀,病理分期:Ⅰ期8例(53.3%),Ⅱ期3例(20.0%),Ⅲ期4例(26.7%);病理表现:肿瘤多呈实性或以实性为主的灰白色包肿块,平均直径(12.6±1.5)cm,囊实相间,镜下主要由透明细胞、鞋钉样细胞和嗜酸性细胞组成;所有患者均行手术治疗,且术后行辅助化疗。生存9例(60.0%),包括Ⅰ期6例,Ⅱ期2例,Ⅲ期1例;6例(40.0%)复发并死亡,包括Ⅰ期2例,Ⅱ期1例,Ⅲ期3例。结论 OCCC早期发现的患者比例高,肿瘤症状出现早,多为腹痛和腹胀,且复发率较高,预后差。
Objective To analyze the pathological features and prognostic factors of 15 cases of Ovarian clear cell carcinoma (OCCC) in order to provide a reference for the clinical treatment of OCCC. Methods The clinical data of 15 patients with OCCC admitted from June 2008 to March 2012 were analyzed, and their pathological features and prognosis were summarized. Results A total of 13 patients (86.7%) had abdominal pain and 11 (73.3%) had abdominal distension. Pathological staging was as follows: stage Ⅰ (8 cases, 53.3%), stage Ⅱ Stage 3 (20.0%), stage Ⅲ 4 cases (26.7%); pathological manifestations: tumor mostly solid or solid-based gray white mass, the average diameter (12.6 ± 1.5) cm, Under the main by the transparent cells, spike-like cells and eosinophils; all patients underwent surgical treatment, and postoperative adjuvant chemotherapy. Survival in 9 cases (60.0%) included 6 cases in stage Ⅰ, 2 cases in stage Ⅱ and 1 case in stage Ⅲ. 6 cases (40.0%) recurred and died, including 2 cases in stage Ⅰ, 1 case in stage Ⅱ and 3 cases in stage Ⅲ. Conclusion OCCC early detection of patients with a high proportion of tumor symptoms appeared early, mostly abdominal pain and abdominal distension, and the recurrence rate is high, the prognosis is poor.