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目的 研究在控制性超排卵 (COH)使用促性腺激素释放激素激动剂 (GnRH -a)的过程中发现妊娠的原因及妊娠结局。方法 回顾性分析 1993年 2月至 2 0 0 1年 11月体外受精或卵母细胞浆内单精子显微注射受精与胚胎移植 (IVF/ICSI -ET)超排卵周期使用GnRH -a过程中发现妊娠的临床资料。结果 在 5 180个IVF/ICSI -ET超排卵周期使用GnRH -a的过程中发现妊娠 2 6例 ,发生率为 0 5 0 % ,其中在输卵管因素、男方因素、子宫内膜异位症、盆腔粘连和不明原因各种不孕中的发生率分别为 0 33%、0 37%、2 30 %、0 97%和0 6 4 %。 2 6例妊娠中宫内妊娠 2 0例 ,其中 15例分娩 17个健康新生儿 ,1例正在妊娠 ,流产 2例 ,失访 2例 ;异位妊娠 6例 ,发生率为 2 3 0 8% (6 / 2 6 ) ,输卵管因素中异位妊娠发生率最高达 5 5 5 6 % (5 / 9)。结论 在超排卵周期使用GnRH -a的过程中应注意发生妊娠的可能。宫内妊娠给予安胎治疗 ,可分娩正常新生儿 ;此种妊娠在子宫内膜异位症患者中发生率较高 ,而异位妊娠发生率则在输卵管因素中最高 ,临床应严密监测异位妊娠的发生情况
Objective To investigate the causes of pregnancy and pregnancy outcomes during the use of gonadotropin-releasing hormone agonist (GnRH-a) in controlled superovulation (COH). Methods A retrospective analysis was performed on the use of GnRH-a during in vitro fertilization or IVF / ICSI-ET superovulation during in vitro fertilization or in oocyte cytosolic sperm injection in oocytes from February 1993 to November 2011 Clinical data of pregnancy. Results In 5 180 IVF / ICSI-ET superovulation cycles, GnRH-a was found in 26 cases of pregnancy, with a prevalence of 0 5 0%. Among them, tubal factors, male factors, endometriosis, pelvic The incidence of adhesions and unexplained infertility were 0 33%, 0 37%, 2 30%, 0 97% and 0 64%, respectively. Twenty-six intrauterine pregnancies were detected in 26 cases of pregnancy, of which 15 delivered 17 healthy newborns, 1 were undergoing pregnancy, 2 were aborted, 2 were lost to follow-up, 6 were ectopic pregnancies with a prevalence of 2380% (6/26). The incidence of tubal ectopic pregnancy was up to 55 65% (5/9). Conclusion GnRH-a in the process of superovulation should pay attention to the possibility of pregnancy. Pregnancy intrauterine pregnancy given tocolysis, normal newborns can be delivered; this pregnancy in patients with higher incidence of endometriosis, while the incidence of ectopic pregnancy in tubal factors in the highest, clinical should be closely monitored ectopic The occurrence of pregnancy