用β－环糊精、顺丁烯二酸酐、氯乙酸和氯化镍反应，合成了β－环糊精衍生物的Ｎｉ２＋配合物，并以此配合物模拟还原酶成功地将顺丁烯二酸酐催化加氢生成丁二酸，反应条件温和，产率比文献报道的高温、高压、ＲａｎｅｙＮｉ催化条件下的产率高１５．１％。 Cyclodextrin, maleic anhydride, chloroacetic acid and nickel chloride were used to synthesize Ni2 + complexes of β-cyclodextrin derivatives. With this complex analogue reductase, Hydrogenation of succinic anhydride to succinic acid gave a mild reaction condition. The yield was 15.1% higher than that reported in the literature under high temperature and high pressure, under the catalytic conditions of RaneyNi.