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目的:观察醒脑静注射液联合阿替普酶治疗急性缺血性脑卒中患者的疗效及对患者认知功能的影响。方法:纳入86例急性缺血性脑卒中患者,按照随机数字表法随机分为观察组与对照组各43例。对照组采用注射用阿替普酶治疗,观察组在对照组治疗基础上结合醒脑静注射液治疗。2组疗程均为14天。观察2组患者治疗前后的神经功能缺损程度(NIHSS)评分、日常生活活动能力(ADL)评分、认知功能情况[采用简易智能状态量表(MMSE)和蒙特利尔认知评估量表(MoCA)进行评价]的变化以及不良反应的发生情况。结果:观察组治疗总有效率(93.02%)高于对照组(74.42%),差异有统计学意义(P<0.05)。治疗后,2组NIHSS评分均较治疗前降低(P<0.05),观察组NIHSS评分低于对照组(P<0.05)。2组ADL评分、MMSE和MoCA评分均较治疗前增加(P<0.05),观察组3项评分均高于对照组(P<0.05)。2组患者均未出现严重不良反应。结论:醒脑静注射液联合阿替普酶治疗急性缺血性脑卒中患者疗效显著,可明显改善认知功能,安全性良好,值得研究。
Objective: To observe the effect of Xingnaojing injection combined with alteplase in the treatment of acute ischemic stroke patients and its effect on cognitive function. Methods: A total of 86 patients with acute ischemic stroke were enrolled and randomly divided into observation group (43 cases) and control group (43 cases) according to the random number table method. Control group with injection of alteplase treatment, the observation group in the control group based on the combination of xingnaojing injection treatment. The two groups were treated for 14 days. The NIHSS score, ADL score and cognitive function were measured before and after treatment in both groups (MMSE and MoCA) Evaluation] changes and the occurrence of adverse reactions. Results: The total effective rate (93.02%) in observation group was higher than that in control group (74.42%), the difference was statistically significant (P <0.05). After treatment, the NIHSS scores in both groups were lower than those before treatment (P <0.05), and the NIHSS scores in the observation group were lower than those in the control group (P <0.05). The scores of ADL, MMSE and MoCA in the two groups were significantly higher than those before treatment (P <0.05). The three scores in the observation group were higher than those in the control group (P <0.05). Two groups of patients did not appear serious adverse reactions. Conclusion: Xingnaojing injection combined with alteplase in the treatment of acute ischemic stroke patients with significant effect, can significantly improve cognitive function, safety is good, worthy of study.