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本文研究了尼古丁对SD大鼠十二指肠溃疡(Du)发生及胃十二指肠粘膜保护因素的影响,结果表明:尼古丁可明显加强半胱胺的致Du作用,对十二指肠基础碳酸氧盐(HCO_3~-)分泌无明显影响,对酸或前列腺素E(PGE)刺激的HCO_3~-分泌则有不同程度的抑制作用。慢性给予尼古丁对胃壁粘液无影响,对十二指肠粘膜细胞的~3H-TdR标记指数有明显抑制作用。结果指示吸烟可促进Du发生,这可能与其对十二指肠HCO_3~-分泌及粘膜细胞增殖的抑制作用有关。
This article studied the effect of nicotine on duodenal ulcer (Du) and gastroduodenal mucosal protective factors in SD rats. The results show that nicotine can significantly enhance the Du role of cysteamine, on the duodenal basis There was no significant effect on the secretion of bicarbonate (HCO_3~-) and inhibition of HCO_3~- secretion by acid or prostaglandin E (PGE) was inhibited to varying degrees. Chronic administration of nicotine had no effect on mucus in the stomach wall, and significantly inhibited the ~3H-TdR labeling index of the duodenal mucosal cells. The results indicate that smoking can promote the occurrence of Du, which may be related to the inhibition of duodenal HCO_3~-secretion and the proliferation of mucosal cells.