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评价新化合物抗炎活性的一个有用指标,是看这些物质对致炎性刺激引起的大鼠脚爪体积增加的影响。本文介绍一种测定大鼠脚爪体积的新方法。此法是用一恒定流量泵将大鼠脚爪排出的水抽回到原容器内所需要的时间,而求得大鼠脚爪体积变化情况。体积是在脚爪自容器中移出后记录的,因此对实验操作者的偏性影响较小。该方法的优点是不需用汞。
A useful indicator for evaluating the anti-inflammatory activity of new compounds is the effect of these agents on the increase in rat paw volume induced by inflammatory stimuli. This article describes a new method for determining the rat paw volume. This method is a constant flow pump rat paw discharge water back into the original container within the time required to obtain the rat paw volume changes. The volume is recorded after the paw has been removed from the container and therefore has less effect on the experimental operator’s bias. The advantage of this method is that no mercury is required.