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目的:探讨NGF早期干预对重度窒息新生儿脑损伤程度及MBP和酸性钙结合蛋白S-100的影响。方法:选取我院2009年1月~2012年12月104例重度窒息复苏新生儿,将其随机分成研究组和对照组,对照组患者对症处理且应用脑蛋白水解物(脑活素)和胞二磷胆碱予以治疗;研究组患者在对照组基础上于出生24小时内予以NGF治疗,分析对比2组HIE发生率,治疗前后血清MBP、S-100改变情况,并予以行为神经评分。结果:2组患者重度HIE发病率,死亡率均无统计学差异(P>0.05);2组出生后3天、7~8天,血清MBP和S-100具有明显统计学差异,2组出生后7~8天和14~16天行为神经评分<35分者对比有统计学差异(P<0.05)。结论:重度窒息新生儿,及早进行NG干预能够降低缺氧缺血性脑受损程度。
Objective: To investigate the effect of early NGF intervention on the degree of brain injury and MBP and S-100 in neonates with severe asphyxia. Methods: One hundred and forty-four neonates with severe asphyxia were recruited in our hospital from January 2009 to December 2012. The neonates were randomly divided into study group and control group. Patients in the control group were treated symptomatically and treated with brain proteolytic enzyme The patients in the study group were treated with NGF within 24 hours after birth on the basis of the control group. The incidence of HIE was compared between the two groups before and after treatment, and the changes of serum MBP and S-100 levels were observed before and after treatment. Results: The morbidity and mortality of severe HIE in two groups were not significantly different (P> 0.05). The levels of MBP and S-100 in serum were significantly different between the two groups at 3 days and 7-8 days after birth After 7 to 8 days and 14 to 16 days behavioral nerve score <35 points were statistically significant differences (P <0.05). Conclusion: Severe asphyxia neonates, early intervention with NG can reduce the degree of hypoxic-ischemic brain damage.