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目的研究基质金属蛋白酶-9(MMP-9)和整合素β3(Integrin β3)在妊娠期高血压疾病患者胎盘组织中的表达,并探讨其与妊娠期高血压疾病发病的关系及两者的相关性。方法采用免疫组织化学染色(SP法)分别检测In-tegrinβ3、MMP-9在10例妊娠期高血压疾病患者及10例正常妊娠者胎盘组织中的表达。结果妊娠期高血压疾病组胎盘Integrinβ3表达明显高于正常妊娠组(P<0.01)。妊娠期高血压疾病组胎盘MMP-9表达明显低于正常妊娠组(P<0.01),且随病情的加重MMP-9的表达有下降趋势,有统计学意义(P<0.05)。结论本研究显示:与正常妊娠组比较妊娠期高血压疾病患者胎盘组织integrinβ3表达明显增加、MMP-9的表达明显减少,且随病情加重有减少趋势。表明integrinβ3、MMP-9可能参与妊娠期高血压疾病的发生和发展。
Objective To investigate the expression of matrix metalloproteinase-9 (MMP-9) and integrin β3 in placenta of patients with hypertensive disorder of pregnancy and its relationship with the incidence of hypertensive disorder complicating pregnancy and the relationship between the two Sex. Methods The expression of In-tegrinβ3 and MMP-9 in placenta of 10 cases of pregnancy-induced hypertension and 10 cases of normal pregnancy were detected by immunohistochemical staining (SP method). Results The placental expression of Integrinβ3 in gestational hypertension group was significantly higher than that in normal pregnancy group (P <0.01). The expression of MMP-9 in placenta of hypertensive disorder complicating pregnancy was significantly lower than that of normal pregnancy group (P <0.01). The expression of MMP-9 was decreased with the increase of disease severity (P <0.05). Conclusion This study shows that compared with normal pregnancy group, the expression of integrinβ3 in placental tissue of patients with gestational hypertension increased significantly, the expression of MMP-9 decreased significantly, and decreased with the progression of the disease. The results showed that integrinβ3 and MMP-9 may participate in the occurrence and development of hypertensive disorder complicating pregnancy.