近十年来,人们对肿瘤机制的认识发生了较大的变化和分歧。一方面越来越多的学者对半个多世纪前提出的体细胞突变理论产生了怀疑并相继提出了如免疫促癌学说和癌干细胞学说等新学说;另一方面更多的癌相关基因被发现和靶向治疗的实施又证实了体细胞突变理论的正确性和可行性。本文就体细胞突变理论作一简要讨论。 Over the past decade, people’s understanding of tumor mechanisms have undergone major changes and differences. On the one hand, more and more scholars have raised doubts about somatic mutation theory put forward more than half a century and successively put forward new theories such as immunopotency theory and cancer stem cell theory; on the other hand, more cancer-related genes have been The implementation of discovery and targeted therapy confirmed the correctness and feasibility of somatic mutation theory. In this paper, a brief discussion of somatic mutation theory.