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目的分析耐多药肺结核患者采用左氧氟沙星联合卷曲霉素治疗的疗效及对其免疫功能与肝功能的影响。方法选取信阳市第五人民医院2012年10月—2016年7月收治的68例耐多药肺结核患者,采用随机数字表法分为观察组(n=34)和对照组(n=34),采用常规化疗治疗对照组患者,采用左氧氟沙星联合卷曲霉素治疗观察组患者,比较两组总有效率、治疗前和治疗后4周免疫功能与肝功能指标水平。结果观察组总有效率为88.24%(30/34),高于对照组总有效率64.71%(22/34),差异具有统计学意义(P<0.05);与对照组相比,观察组治疗后4周Ig M、Ig A、Ig G、CD4+较高,CD8+较低,差异具有统计学意义(P<0.05)。结论耐多药肺结核患者采用左氧氟沙星联合卷曲霉素治疗可增强患者免疫功能,提高治疗效果,且不会增加肝脏负担。
Objective To analyze the effect of levofloxacin plus capmycian on patients with multidrug-resistant pulmonary tuberculosis and their effects on immune function and liver function. Methods Sixty-eight MDR-TB patients admitted to the Fifth People’s Hospital of Xinyang from October 2012 to July 2016 were randomly divided into observation group (n = 34) and control group (n = 34) Patients in the control group were treated with conventional chemotherapy. Patients in the observation group were treated with levofloxacin and capreomycin, and the total effective rate, the immune function and the level of liver function before and after 4 weeks of treatment were compared. Results The total effective rate in the observation group was 88.24% (30/34), higher than that in the control group (64.71%, 22/34), the difference was statistically significant (P <0.05). Compared with the control group, the observation group After 4 weeks, Ig M, Ig A, Ig G, CD4 + and CD8 + were lower, the difference was statistically significant (P <0.05). Conclusion Levofloxacin and capreomycin in patients with multidrug-resistant pulmonary tuberculosis can enhance immune function and improve the therapeutic effect without increasing the burden on the liver.